Tablet Presentation

Each Film Coated Tablet Contains:
Sitagliptin Phosphate Monohydrate IP 64.25 mg
Eq. to Sitagliptin 50 mg
Metformin Hydrochloride IP 500/1000 mg

Sitagliptin & Metformin Tablet is a dipeptidyl peptidase-4 (DPP-4) inhibitor and biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. They help your pancreas produce more insulin, facilitate the effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, they provide better control of blood sugar.

What is type 2 diabetes?

Type 2 diabetes is a condition in which your body does not make enough insulin, and the insulin that your body produces does not work as well as it should. Your body can also make too much sugar. When this happens, sugar (glucose) builds up in the blood.

Indication

Sitagliptin & metformin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
Note: Sitagliptin and Metformin Tablet should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis

Mechanism of action

Sitagliptin is a member of the gliptin class of anti-diabetic medications. Its mechanism of action is through inhibition of dipeptidyl peptidase-4 (DPP-4), an enzyme that acts to degrade and inactivate glucagon-like peptide-1 (GLP-1). Sitagliptin works by increasing the amount of insulin that your body makes. Insulin is the hormone that controls sugar levels in your blood.

Side Effects

• Headache
• Upper respiratory infection
• Stuffy or runny nose and sore throat
• Upset stomach
• Stomach pain

Contraindication

• Sitagliptin and Metformin is contraindicated in patients with previous hypersensitivity to Sitagliptin and Metformin or any other component of this drug
• If any have kidney problems, heart diseases
• Type 1 disease
• Metabolic acidosis, including diabetic ketoacidosis
• Vitamin B12 deficiency: Metformin may lower Vitamin B12 levels

Drug Interaction

Tell your doctor if you are taking digoxin (a medicine used to treat irregular heartbeat and other heart problems).

Warning & Precaution

• During Pregnancy and Breastfeeding please consult your doctor before taking any medicine
• This medicine has no or negligible influence on the ability to drive and use machines

Dosage

Metformin and sitagliptin combination should be taken with meals to help reduce any stomach upset but it is better to take it at a fixed time.
Or Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sitagliptin Tablet may be taken with or without food, you should keep taking this medicine for as long as your doctor recommends.

Storage

Store in a cool, dry & dark place. Protected from direct sunlight.

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